HUDROXILIMINE HYDROCHLORIDE is a reducing agent that is soluble in aqueous buffers. Hydroxylamine HCl is a reagent used in many biomolecular applications, including the cleavage of Glycine- Asparagine (Gly-Asn) in proteins and peptides.
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PHYSICAL AND CHEMICAL INFORMATION:
HUDROXILIMINE HYDROCHLORIDE Molecular Formula: NH2OH.HCl or ClH4NO
Molecular Weight: 69.49 g/mol
Melting point: 154°C
Density: 1.7 g/cm³
Solubility in water, g/100ml at 25°C: 94 (freely soluble)
Appearance:
Hydroxylamine hydrochloride appears as colorless or off-white crystalline solid. pH (0.1 molar aqueous solution) 3.4. pH (0.2 molar aqueous solution) 3.2. (NTP, 1992)
Use and application :
Hydroxylammonium chloride is used in organic synthesis for preparation of oximes and hydroxamic acids from carboxylic acids, N- and O- substituted hydroxyamines, and addition reactions of carbon-carbon double bond.
During the acetyl bromide method of extracting lignin from lignocellulosic biomass, hydroxylammonium chloride can be used to remove bromine and polybromide from the solution.
In surface treatments, it is used in the preparation of anti-skinning agents, corrosion inhibitors, and cleaner additives. It is also a starting material for pharmaceuticals and agrochemicals manufacturing. In the rubber and plastics industries, it is an antioxidant, vulcanization accelerator, and radical scavenger.
It is also used as a fixative for textile dyes, auxiliary in some dyeing processes, as a metal extraction and flotation aid, as an antioxidant in fatty acids and soaps, and as a color stabilizer and emulsion additive in color films.
It is also used in analytic chemistry in the analysis of iron in the water combined with α,α-dipyridyl. The hydroxylammonium chloride transforms all the iron in Fe2+, that then forms a coordination complex with the dipyridyl.
NB : Chemical dangers
Decomposes slowly on contact with moisture. Upon heating, toxic fumes are formed. Decomposes on heating. This generates explosion hazard. The solution in water is a weak acid. Attacks many metals.
EXPOSURE AND HEALTH EFFECTS of HUDROXILIMINE HYDROCHLORIDE
Routes of exposure
The substance can be absorbed into the body by inhalation of its aerosol, through the skin and by ingestion.
Effects of short-term exposure
The substance is irritating to the eyes, skin and respiratory tract. The substance may cause effects on the blood. This may result in the formation of methaemoglobin. Medical observation is indicated
Inhalation risk
Evaporation at 20°C is negligible; a harmful concentration of airborne particles can, however, be reached quickly when dispersed.
Effects of long-term or repeated exposure
Repeated or prolonged contact may cause skin sensitization. The substance may have effects on the blood. This may result in the formation of methaemoglobin. Tumours have been detected in experimental animals but may not be relevant to humans
Symptoms when exposed to mishandling
SYMPTOMS:
Emergency call a doctor and explain your symptoms :
Inhalation: Blue lips, nails and skin. Headache. Dizziness. Nausea. Confusion. Convulsions. Unconsciousness.
Skin : MAY BE ABSORBED! Redness. Pain. Further see Inhalation.
Eyes: Redness. Pain.
Ingestion : See Inhalation.
PREVENTION :
– Use ventilation (not if powder). Use local exhaust or breathing protection.
– Protective gloves.
– Wear safety goggles or eye protection in combination with breathing protection if powder.
– Do not eat, drink, or smoke during work.
FIRE FIGHTING
In case of fire in the surroundings, use appropriate extinguishing media.
FIRST AID :
Fresh air, rest. Refer for medical attention. / in the case of Inhalation
Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention . / in case of skin irritation
First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention. / in case of eye irritation
Rinse mouth. Give a slurry of activated charcoal in water to drink. Refer for medical attention . / in case of indigestion
