Piperonyl Methyl Ketone (PMK) CAS number is 4676-39-5

Description

Piperonyl Methyl Ketone (PMK)

Piperonyl Methyl Ketone (PMK) , Piperonyl Methyl Ketone is a yellowish oily chemical. It consists of a  phenylacetone moiety which is substituted with a methylenedioxy functional group. Since this is an unstable compound, it is stored in the room temperature for preserving it. This chemical is a precursor or intermediate in the process of synthesis of methylenedioxy phenethylamines and amphetamines, which includes 3,4-MDMA. It is also found as an impurity in the manufacturing of methylenedioxy phenethylamines. Its CAS number is 4676-39-5

What are the other names in which Piperonyl Methyl Ketone (PMK) is known in the market?

MDP2P
3,4-Methylenedioxyphenylpropan-2-one
NSC 16688
EINECS 225-128-6
AI3-30059
AC1L2V5Y
PMK
PVI-2

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1.It is used in the synthesis of Talampanel, which is used in the investigation for the treatment of epilepsy, malignant gliomas

and amyotrophic lateral sclerosis. It acts as a non-competitive antagonist of the AMPA receptor, which is a kind of ionotropic glutamate receptor present in the central nervous system. Piperonyl Methyl Ketone (PMK)

It is found to be effective for epilepsy in the clinical trials but there was a suspension of the process owing to its poor pharmacokinetic profile such as its short terminal half-life of 3 hours which created the need of multiple doses per day. Order Piperonyl Methyl Ketone (PMK Glycidate)

2.Manufacturing Podilfen.

3.Protokylol manufacturing. It is a  β-adrenergic receptor agonist which is used as a bronchodilator in Europe and the United States. Buy Piperonyl Methyl Ketone (PMK)

4.It is used for forensic and research applications.

5.It is used as a metabolite of 3,4 Methylenedioxyethylamphetamine (MDE) and 3,4-(Methylenedioxy)methamphetamine (MDMA).

How is Piperonyl Methyl Ketone (PMK) prepared?

This chemical is synthesised from safrole or its isomer isosafrole through the process of oxidation using the Wacker oxidation or peroxy acid oxidation methods.

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Here are some of the popular chemical vendors of this chemical:

AHH Chemical co.,Ltd
TCI (Tokyo Chemical Industry)
Chem-Space.com Database
Achemtek
Life Chemicals
Hangzhou APIChem Technology
Angene Chemical
MuseChem
Yuhao Chemical
Aurora Fine Chemicals LLC
ChemShuttle
Alfa Chemistry
AKos Consulting & Solutions
Boc Sciences

Properties of Piperonyl Methyl Ketone (PMK):

Property Value
Molecular Weight  178.187 g/mol
Exact Mass 178.063 g/mol
Appearance Yellowish green liquid
Density 1.211 g/cm3
Boiling point 290 °C (554 °F; 563 K)
CAS number 4676-39-5.
Purity 99%

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What safety precautions need to be kept in mind while using this chemical?

Here are the precautions which you need to take while handling

On coming in contact with the skin, irritation or skin corrosion occurs. So make sure to avoid contact with the chemical directly.
It leads to serious irritation of the eyes and even eyes can be damaged when it gets in contact with it.
It may even cause respiratory irritation. It has characteristics of causing target organ toxicity even on a single exposure. Irritation may be experienced in the respiratory tract.
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